 Brain synapses use alternative protein assembly to regulate information processingAt brain synapses, the nano-machine for protein clearance can regulate information processing at synapses using just a component of the full machinery (Sun et al., Science 2023) |  Subcellular compartmentalisation drives parallel processingAn individual neuron hosts about 10000 synapses (dark puncta) in its expansive dendritic and axonal arbour |  The prevalence of synaptic protein synthesisLocal ribosomes supply proteins for synaptic maintenance and plasticity (Sun et al 2021). Graphic by Julia Kuhl |  Super-resolved ribosome particlesRibosome small subunits (left), monoribosomes (middle), and polyribosomes (right) were visualised at single-molecule resolution (Sun et al 2021). |  'BioNumbers' of a neuron'BioNumbers' of a neuron and its proteins (from Review: Sun and Schuman 2022) |
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THE SYNAPTIC LOGISTICS LAB
The Sun lab investigates the protein machinery that manages the molecular homeostasis of brain synapses using quantitative in situ single-molecule approaches. Our core hypothesis: molecular supply puts constraints on synaptic function, and the logistic vulnerabilities of brain synapses seed the onset of neurological diseases.
We are looking for talents!
A postdoc position funded by PROMEMO & DANDRITE to study the impact of toxic proteins on synaptic molecular homeostasis is now open (deadline Jan. 31st, 2025). Apply here
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The Lab of Synaptic Logistics is located in the Danish Research Institute of Translational Neuroscience (DANDRITE), a Nordic-EMBL partner at Aarhus University, Denmark.
CONTACT
Dr. Chao Sun
Aarhus University, DANDRITE
Universitetsbyen 81, 1874-111
Aarhus 8000, Denmark