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 Brain synapses use alternative protein assembly to regulate information processingAt brain synapses, the nano-machine for protein clearance can regulate information processing at synapses using just a component of the full machinery (Sun et al., Science 2023) |  Subcellular compartmentalisation drives parallel processingAn individual neuron hosts about 10000 synapses (dark puncta) in its expansive dendritic and axonal arbour |  The prevalence of synaptic protein synthesisLocal ribosomes supply proteins for synaptic maintenance and plasticity (Sun et al 2021). Graphic by Julia Kuhl |  Super-resolved ribosome particlesRibosome small subunits (left), monoribosomes (middle), and polyribosomes (right) were visualised at single-molecule resolution (Sun et al 2021). |
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 'BioNumbers' of a neuron'BioNumbers' of a neuron and its proteins (from Review: Sun and Schuman 2022) |
THE SYNAPTIC LOGISTICS LAB
The Sun lab investigates protein machines that manage the molecular logistics of brain synapses using quantitative spatial proteomics approaches. Our core hypothesis: molecular supply puts constraints on synaptic function, and the logistic vulnerabilities of brain synapses seed the onset of neurological diseases.
We are looking for talented master/PhD students & postdocs
The Lab of Synaptic Logistics is located in the Danish Research Institute of Translational Neuroscience (DANDRITE), Aarhus University, Denmark.
CONTACT
Dr. Chao Sun
Aarhus University, DANDRITE
Universitetsbyen 81, 1874-111
Aarhus 8000, Denmark
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