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 Brain synapses use alternative protein assembly to regulate information processingAt brain synapses, the nano-machine for protein clearance can regulate information processing at synapses using just a component of the full machinery (Sun et al., Science 2023) |  Subcellular compartmentalisation drives parallel processingAn individual neuron hosts about 10000 synapses (dark puncta) in its expansive dendritic and axonal arbour |  The prevalence of synaptic protein synthesisLocal ribosomes supply proteins for synaptic maintenance and plasticity (Sun et al 2021). Graphic by Julia Kuhl |  Super-resolved ribosome particlesRibosome small subunits (left), monoribosomes (middle), and polyribosomes (right) were visualised at single-molecule resolution (Sun et al 2021). |  'BioNumbers' of a neuron'BioNumbers' of a neuron and its proteins (from Review: Sun and Schuman 2022) |
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THE SYNAPTIC LOGISTICS LAB
The Sun lab investigates the protein machinery that manages the molecular homeostasis of brain synapses using quantitative in situ single-molecule approaches. Our core hypothesis: molecular supply puts constraints on synaptic function, and the logistic vulnerabilities of brain synapses seed the onset of neurological diseases.
We are looking for talents!
Postdoc position funded by PROMEMO & Lundbeck Foundation to study molecular homeostasis at synapses is now open (deadline Sept. 6th, 2024). Apply here
The Lab of Synaptic Logistics is located in the Danish Research Institute of Translational Neuroscience (DANDRITE), a Nordic-EMBL partner at Aarhus University, Denmark.
CONTACT
Dr. Chao Sun
Aarhus University, DANDRITE
Universitetsbyen 81, 1874-111
Aarhus 8000, Denmark
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